Abstract: 3D craniofacial model reconstruction from skull data has been a challenging research topic for many years.In this paper,a new craniofacial reconstruction algorithm based on automatic calibration of feature points is presented.First,the feature points are calibrated on skull model by landmarks' automatic calibration algorithm.Then the Laplace coordinate based mesh deformation is introduced to the template based craniofacial reconstruction technique to achieve the craniofacial reconstruction of skull.In order to verify the reliability of the reconstruction results,an assessment method is presented,which combines the similarity of overall facial features and local facial features.According to the experimental results,the algorithm greatly improves the efficiency of the preliminary work of craniofacial reconstruction,and achieves a satisfactory result,meanwhile the assessment method for the reconstruction results obtains consensus on the subjective and objective evaluation,and is a good indicator for craniofacial reconstruction results.