Abstract: Craniofacial reconstruction has important applications in the domain of forensic science.In order to estimate the appearance of the unidentified skull,this paper proposes a novel framework of craniofacial reconstruction by combining dense point sets registration and organs(nose,eyes and mouth) registration.We introduce an evaluation method of craniofacial reconstruction based on the soft-tissue thickness.Firstly,a 3D model database of faces and skulls is built and processed.Secondly,registration point sets are selected and their correspondence is established.The iterative closest point(ICP) and thin-plate spline(TPS) are adopted to achieve registration from the reference skull to the unidentified skull.Furthermore,the soft-tissue thickness of the reference skull is taken as the initial craniofacial estimation of the unidentified skull.Finally,a method of organ registration is presented to improve accuracy of the craniofacial reconstruction.In order to verify the correctness of the algorithm,the soft-tissue thickness is compared between the final result and the reference.The feasibility and usability of the algorithm are confirmed through our experiments.