Abstract: A B-spline based functionally graded teeth modeling method is proposed in this paper.By discretizing CAD teeth model or scanning teeth object with CT, points cloud in slice model of the teeth is obtained.Multiple graded sources and corresponding material functions are introduced to control geometry information and material distribution in solid model constructed by B-spline tension product interpolation.This approach compounds the advantages of analysis and discretization methods, thus it is capable of representing geometry information precisely and complicated material distribution, which solves the problems caused by using analysis or discretization method separately and provides an approach to model functionally graded material (FGM) teeth with both bio-mechanic property and bio-compatibility.At last, an example of teeth modeling with the proposed method is illustrated to validate its feasibility.