Abstract: Targeting at the problem of high defect rate in CMOS/nanowire/MOLecular hybrid（CMOL） circuits,a defect-free area extraction based defect-unaware mapping method is proposed.First,cooperative detection of minimum logical units with nanodevices are utilized to accelerate the extraction.Then evolutionary algorithm is introduced to implement logic mapping in defect-free area.By designing selection strategy,fitness function and elitism strategy to model bio-evolution process,the solution is improved by global searching.Experimental results demonstrate the improvement of the proposed method in CPU time and wire length.