Abstract: The traditional image deformation methods based on Moving Least Square (MLS) can produce local distortions, due to the fact that the explicit topological information of the character in the image is not taken into account.In this paper, we present a novel approach of MLS Cartoon Character Deformation Driven by Skeleton.Firstly, the underlying 2D shape for the character is extracted and triangulated into a mesh.Then the skeleton is constructed according to the topology information of 2D shape and binded to the underlying model automatically.Finally, the 2D shape is animated by using MLS deformation with the adjustment of the joints in the skeleton.In our approach, every vertex is bounded to the corresponding skeleton, and it can not be affected by other points.Thus, our method eliminates the local distortions in the characters and enhances the realisticness of the animation.The experimental results have demonstrated that our deformation approach can produce higher quality of deformation than previous method, and it can be widely used in cartoon animation.