Abstract: A hybrid genetic based mapping algorithm for CMOL cell mapping is proposed.First,an arbitrary Boolean logic circuit is converted to NOR gate based netlist.Then the initial population is constructed by encoding chromosomes of the circuit.Two dimensional crossover and mutation operators are implemented to explore global solution space simultaneously with simulated annealing based local search algorithm for improving individuals based on fitness.Experimental results on ISCAS and MCNC benchmarks indicates that the proposed method can not only obtain better area and smaller delay,but also handle larger benchmarks with faster CPU runtime.