Abstract: At present, there is no research on deformation of skull base tumors based on interaction of mucosal forceps. As one of the main tools for nasal-skull base surgery, the research on mucosal forceps can provide technical support for nose-skull base virtual surgery system. First, we reconstruct chordoma model based on CT, and create mucosal forceps model with reference to real object. Second, we do accurate collision detection based on the positional relationship between collision point and triangle patches, and distribute external force to vertices based on the distance between collision point and triangle patch vertices. Then, we simulate the tumor deformation based on the Voigt model, and use the 4-order Runge-Kutta method to solve the dynamic equation. Finally, we use Geomagic Touch device and spring-damper model to implement force feedback. The chordoma model used has 2 601 vertices. The experimental results of CPU i7-9700K and GPU 1660Ti show: The deformation effect is consistent with the viscoelasticity, stress-strain nonlinearity and strain hysteresis of soft tissue; The frame rate exceeds 60 and reaches real-time requirement; The questionnaire survey of 17 physicians also get a good evaluation.