Abstract: The lack consideration of manufacturing information such as manufacturing feature size,machining accuracy,form and position tolerance,etc.leads to the poor effect reuse of 3D process model sequence in parts manufacturing process.For that problem,this paper proposes a 3D process model sequence reuse method based on manufacturing semantics.Firstly,the 3D process model sequence in the process route is optimized by using graph isomorphism to reduce the search space.Secondly,the sub-image isomorphism is used to match the processing features of the 3D process model,and the manufacturing information is used to match the processing features to perform pre-processing and similarity evaluation,by which the 3D process model with the most similar processing features is obtained.Thirdly,a 3D process model sequence optimization algorithm is designed to obtain isomorphic three-dimensional process model sequences.Finally,the process design process of a certain shaft part is taken as an example to verify the results.The results show that the purposed method can accurately reuse process model sequence,and has good application effect.