Abstract: In order to verify the rationality of personalized design in femoral prosthesis matching performance,and provide a reference for the personalized design method of femoral prosthesis, this paper presents amethod for the analysis of femoral prosthesis matching by using the osteotomy coverage rate and prosthesiscoincidence degree. First, this study defines the osteotomy coverage rate of femoral prosthesis based on theconcept of tibial plateau coverage rate, and introduces the concept of prosthesis coincidence degree to quantifythe matching degree of the femoral prosthesis on the osteotomy plane and the shape respectively. Thenthe 3D model of knee joint is reconstructed based on CT scanning data, and a personalized femoral prosthesisis designed based on the surface feature which was extracted from the model. The personalized prosthesiswas implanted by computer simulation with the other three types of femoral prosthesis of NexGen, GEMINIand LEGION, and the values of osteotomy coverage rate and prosthesis coincidence degree of the four typefemoral prostheses are calculated in the end. The results show that the matching performance of the personalizedfemoral prosthesis is better than the standard prostheses on the osteotomy surface and the shape of prosthesis, and the indexes of osteotomy coverage rate and prosthesis coincidence degree can be used toanalyze and evaluate the prosthesis matching performance systematically. The value of the two indicatorscan be used as an important reference for the design of personalized knee prosthesis.