Abstract: In order to achieve “property-oriented” design of microstructures for heterogeneous materials and perform mesomechanics calculations for virtual failure analysis of the microstructure, awe employed Voronoi tessellation algorithm, aVisual C＋＋ compiling codes along with OpenGL tools to develop a software system, aProDesign, a which can be used to simulate 2D microstructures of polycrystals-based composites．The C compiling codes together with Python scripts are used to achieve CAE modeling in ABAQUS for the microstructures．The calculation of mesomechanical responses of the microstructures is realized in a numerical manner．Based on the calculation, a “materials structure weakness” of the microstructures can be identified．Microcrack initiation and subsequent propagation in a microstructure can be quantitatively evaluated． The behavior of virtual failure of the microstructure can therefore be deduced．