Abstract: For large screen smartphones, it is difficult for users to manipulate distant targets which are prone to erroneous target selections. Aiming at solving the problem, this paper qualitatively investigates the users’ habits of manipulating mobile phones and then presents the users’ natural touch area on the screen. Target selection techniques are comparatively explored with respect to the hand structures and the touch characteristics of smart-phone, and 3 other improved target selection techniques over the traditional direct selection technique, which are virtual screen technique, edge response technique, and finger-drop trigger technique, are designed. Comparative experimental result analysis shows that 3 improved techniques are more effective than traditional direct selection technique in selection time, error rate and subjective evaluation. Detailed analysis further shows that finger-drop trigger technique performs the best comprehensively. The techniques proposed in this paper can improve the single-handed operational performance and the user experience for large screen smartphones.