Abstract: The application of virtual reality (VR) is exerting an increasingly pivotal role in neurorehabilitation. VR provides patients with an interactive and personalized environment, promoting motor learning through multimodal sensory information. In this comprehensive review of the utilization of VR in neuromotor rehabilitation, we encompass: (1) the mechanisms of VR in enhancing neurological function; (2) the crucial elements in the design of virtual rehabilitation environments; (3) the application of VR in the rehabilitation of stroke and spinal cord injury (SCI); (4) the challenges and future directions of VR in neurorehabilitation applications. We aspire that this review will offer valuable theoretical and technical references for clinical applications or experiments in the integration of VR into neuromotor rehabilitation.