Abstract: Animation is ubiquitous in the application of smart phone,in fact it is one of the most popular functions.In this paper,we propose the principles,methods and guidelines of smart phone’s animation design,and conduct the comprehensive discussion on the natural interaction between human and smart phone from the view point of the experience value and commercial value.Through the case study,analyze the animation design of the multiple scenarios,and build up the correspondence of human-machine natural interaction.The practice shows that the proposal is convenient with the easy going for design,capturing accurate information and user-friendly.