Abstract: The time complexity was very high for determining adjacency relationship of the fragments,when reassembling archaeological fragments.Due to damaged,there was somewhat geometrical characteristic missing in the fracture surface of cultural relics.It can lead to some errors for matching or reassembling.This paper proposed an effective reassembly pipeline based on feature descriptors of key points.Firstly,the integrated template with similar geometry to the patchwork was available in some reassembly tasks,and Intrinsic Shape Signature(ISS)algorithm was used to extract key points on intact regions of the model and fractured fragment respectively.Then,the Fast Point Feature Histograms(FPFH)feature descriptors were calculated;The adjacency relations between the fracture surfaces were determined by comparing the similarity of FPFH feature descriptor.Finally,multiple fragments were reorganized by sequential splicing and Iterative Closest Point(ICP)algorithm was used to achieve fine registration.The experimental results show that the proposed method can improve efficiency of 3D archaeological fragment reassembly.