Abstract: Considering the features of interior designs, with the significant color difference between regions and the rich colorfulness, this paper proposes a color transfer algorithm for interior designs through matching regions based on topological information. First, the segmentation of interior design images is introduced, then the calculation of topological information of each region is proposed to determine the match relation between regions, thus improving the accuracy of color transfer between images. Secondly, to improve the integrity of color transfer, not only the color transfer is introduced between matched regions, but also the color adjustment is introduced for regions without corresponding target region. Finally, the color harmony algorithm is introduced to reduce the influence of unexpected color generated in the procedure of color transfer, thus improving the harmony of final image. Experimental results show that the proposed algorithm not only can preserve the richness of the image color in the overall situation, but also can get better matching relation and the color adjustment result in the local area, thus generating better color transfer results.